Preferred Label : Nitric Oxide-Releasing Acetylsalicylic Acid Derivative;
NCIt synonyms : Nitric Oxide-Releasing Aspirin Derivative; Nitroaspirin; Benzoic Acid, 2-(Acetyl-oxy)-3-[(nitrooxy)methyl]phenyl Ester;
NCIt related terms : NCX-4016; NCX 4016;
NCIt definition : A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory,
analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities.
The acetylsalicylic acid derivative moiety of this agent inhibits the activities of
cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes.
A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory,
anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results
in an irreversible inhibition of platelet aggregation. NO donation by this agent,
after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric
mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins.
In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases
and may induce apoptosis through caspase-mediated mechanisms.;
Alternative definition : NCI-GLOSS: A substance being studied in the prevention of colorectal cancer. It is
a form of aspirin that gives off nitric oxide gas and is less irritating to the lining
of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory
drug (NSAID).;
UNII : EH04H13L6B;
CAS number : 175033-36-0;
Codes from synonyms : CDR0000523326; 20408; CDR0000488417;
Origin ID : C61499;
UMLS CUI : C0531264;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
