Preferred Label : Selective Estrogen Receptor Modulator TAS-108;
NCIt synonyms : (7)-21-[4-[(diethylamino)methyl]-2-methoxyphenoxy]-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol
2-hydroxy-1,2,3-propanetricarboxylate;
NCIt related terms : SR 16234; TAS-108;
NCIt definition : A synthetic, antiestrogenic steroidal compound with potential antitumor activity.
TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in
the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage
of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an
inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial
agonist of the estrogenic receptor beta (ERb), expressed in many tissues including
the central nervous system, urogenital tract, bone and cardiovascular system, thereby
exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor
Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that
inhibits the activities of the estrogen receptors, which may contribute to the antitumor
activity of TAS-108.;
UNII : 9B29N23K7E;
CAS number : 354808-47-2;
Molecule name : SR16234;
Codes from synonyms : 50689;
Origin ID : C61494;
UMLS CUI : C1435232;
Automatic exact mappings (from CISMeF team)
- TS 108 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- TS 108 [MeSH Supplementary Concept]
- concept_is_in_subset
