Preferred Label : Adenovirus Encoding Recombinant Human Endostatin;
NCIt synonyms : Ad-rhENDO;
NCIt definition : A replication-defective, recombinant oncolytic adenovirus encoding human endostatin
with potential antineoplastic activity. Endostatin, a 20 kDa C-terminal proteolytic
fragment of collagen XVIII, is an important angiogenesis inhibitor. Upon intratumoral
administration, the adenovirus infects and replicates in tumor cells. The expressed
endostatin may inhibit endothelial cell proliferation and angiogenesis which may result
in a reduction of tumor growth.;
Molecule name : E10A;
Origin ID : C61492;
UMLS CUI : C1831833;
Semantic type(s)
- concept_is_in_subset
