Preferred Label : Terameprocol;
NCIt synonyms : 1,1'-(2,3-Dimethyl-1,4-butanediyl)bis(3,4-dimethoxybenzene); M4N; TMNDGA; Tetramethoxynordihydroguaiaretic Acid; Tetra-O-methyl-NDGA;
NCIt related terms : tetra-O-methyl nordihydroguaiaretic acid; EM-1421; tetra-O-methyl NDGA;
NCIt definition : A synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional
inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities.
Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding
domains within gene promoter regions during DNA synthesis. In virally-infected cells,
blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity
and gene expression, thereby inhibiting viral transcription and replication. In tumor
cells, blockage of Sp1 binding sites by this agent interferes with the transcription
of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular
endothelial growth factor (VEGF), which are overexpressed in a variety of cancers.
By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce
tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks proteins
needed for cancer growth. It is a type of transcriptional inhibitor.;
UNII : 53YET703F2;
InChIKey : ORQFDHFZSMXRLM-IYBDPMFKSA-N;
CAS number : 24150-24-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 24150-24-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : EM-1421;
Chemical formula : C22H30O4;
NSC code : 136955;
Codes from synonyms : CDR0000556428; CDR0000556430; CDR0000532133;
Origin ID : C61441;
UMLS CUI : C0654036;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
