Preferred Label : Pegylated Liposomal Belotecan;
NCIt synonyms : STEALTH Liposomal Belotecan;
NCIt definition : A sterically stabilized, pegylated liposomal formulation containing belotecan, a semi-synthetic
analogue of campthotecin with potential antitumor activity. Belotecan inhibits the
action of topoisomerase I, an enzyme that produces reversible single-strand breaks
in DNA during DNA replication. This agent stabilizes the topoisomerase I and DNA complex,
resulting in the inhibition of religation of DNA breaks, inhibition of DNA replication,
and apoptotic cell death. The polyethylene glycol coating allows for greater plasma
circulation time, thus enhancing the concentration of belotecan at the tumor site.
Encapsulation of belotecan preserves the active lactone form, resulting in an increased
cytotoxic effect of belotecan.;
Molecule name : S-CKD602;
Origin ID : C61437;
UMLS CUI : C2987657;
Semantic type(s)
- concept_is_in_subset
