Preferred Label : SR-BP1/HSI Inhibitor SR31747A;
NCIt synonyms : SR31747A;
NCIt definition : A synthetic peripheral sigma receptor ligand with immunomodulatory and potential antitumor
activities. Although the exact mechanism by which SR31747A exerts its antitumor effects
has not been fully established, SR31747A binds to and inhibits the sigma1 receptor
(SR31747A-binding protein-1 or SR-BP1), human sterol isomerase (HSI), also known as
emopamil-binding protein (EBP), and the sigma2 receptor, which may result in a reduction
in tumor cell proliferation and tumor cell apoptosis. In addition, this agent inhibits
the production of pro-inflammatory cytokines while increasing anti-inflammatory cytokines.
Upregulated in various cancers, the sigma1 and sigma2 receptors and human sterol isomerase
are proteins that are involved in the regulation of cell proliferation and survival.;
NCI Metathesaurus CUI : CL937293;
Origin ID : C61435;
UMLS CUI : C4764306;
Semantic type(s)
- concept_is_in_subset
