Stage IVB Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

Preferred Label : Stage IVB Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7;

NCIt synonyms : Stage IVB Nasopharynx Keratinizing Squamous Cell Carcinoma; Stage IVB Keratinizing Squamous Cell Carcinoma of Nasopharynx; Stage IVB Keratinizing Epidermoid Carcinoma of the Nasopharynx; Stage IVB Keratinizing Squamous Cell Carcinoma of the Nasopharynx; Stage IVB Nasopharyngeal Keratinizing Squamous Cell Carcinoma; Stage IVB Nasopharyngeal Keratinizing Epidermoid Carcinoma; Stage IVB Keratinizing Epidermoid Carcinoma of Nasopharynx; Stage IVB Nasopharynx Keratinizing Epidermoid Carcinoma; Stage IVB Nasopharyngeal Squamous Cell Carcinoma;

NCIt related terms : Stage IVB Nasopharyngeal Throat Keratinizing Squamous Cell Cancer;

NCIt definition : Stage IVB includes: Any T, N3, M0. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. M0: No distant metastasis. (AJCC 7th ed.);

Neoplastic status : Malignant;

Details

Origin ID

C6138;

UMLS CUI

C1336380;

Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Headache [NCIt concept]
- Nasal Obstruction [NCIt concept]
- Neck Mass [NCIt concept]
- Rhinorrhea [NCIt concept]
- Tinnitus [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Keratinizing Malignant Squamous Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Keratin Pearls Formation [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Squamous Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Nasopharynx Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
- Throat [NCIt concept]
disease_is_stage
- AJCC v7 Stage [NCIt concept]
- Stage IV [NCIt concept]
- Stage IVB [NCIt concept]
disease_mapped_to_gene
- HLA-A Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 11q [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 14q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 9p [NCIt concept]
- Loss of Chromosome 9q [NCIt concept]
disease_may_have_molecular_abnormality
- CDKN2A Gene Inactivation [NCIt concept]
- EGFR Protein Overexpression [NCIt concept]
- RASSF1A Gene Inactivation [NCIt concept]

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