NCIt synonyms : Gastrin/cholecystokinin Type B Receptor Inhibitor Z-360;
NCIt definition : A selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin
2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds
to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin,
a peptide hormone frequently associated with the proliferation of gastrointestinal
and pancreatic tumor cells.;