NCIt definition : The hydrochloride salt of xaliproden, an orally-active, synthetic, non-peptidic 5-hydroxytryptamine
(5-HT) 1A receptor agonist with neurotrophic and neuroprotective activities. Although
its mechanism of action is not fully understood, xaliproden appears to either mimic
the effects of neurotrophins or stimulate their synthesis, thereby stimulating neuronal
cell differentiation and proliferation and inhibiting neuronal cell death. The neuroprotective
effect of this agent involves the activation of MAP kinase pathways via stimulation
of the 5-HT1A receptor.;