Preferred Label : Oligonucleotide SPC2996;
NCIt synonyms : SPC2996 Oligonucleotide;
NCIt definition : A synthetic antisense oligonucleotide against Bcl-2 messenger RNA with potential antitumor
activity. Oligonucleotide SPC2996 binds to and inactivates Bcl-2 mRNA, thereby inhibiting
the expression of Bcl-2 protein, promoting tumor cell apoptosis, and potentially enhancing
the efficacy of standard cytotoxic chemotherapy. Linked to tumor drug resistance,
the antiapoptotic protein Bcl-2 is upregulated in several types of cancers.;
Origin ID : C61325;
UMLS CUI : C1831825;
Semantic type(s)
- concept_is_in_subset
