Methazolamide - CISMeF

Preferred Label : Methazolamide;

NCIt synonyms : N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide;

NCIt definition : A sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.;

UNII : W733B0S9SD;

InChIKey : FLOSMHQXBMRNHR-QPJJXVBHSA-N;

CAS number : 554-57-4;

Drug name : MZM; Neptazane; Glauctabs;

Chemical formula : C5H8N4O3S2;

Details

Origin ID

C61318;

UMLS CUI

C0025631;

Currated CISMeF NLP mapping
- Methazolamide [ICD-11 Extension code]
- Methazolamide (substance) [SNOMED CT concept]
- Product containing methazolamide (medicinal product) [SNOMED CT concept]
- methazolAMIDE [LOINC component]
- methazolamide [Substance BNPC]
- methazolamide [MeSH Descriptor]
- methazolamide [MeSH concept]
- methazolamide [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Methazolamide [ICD-11 Extension code]
- Methazolamide (substance) [SNOMED CT concept]
- Product containing methazolamide (medicinal product) [SNOMED CT concept]
- methazolAMIDE [LOINC component]
- methazolamide [ATC Code]
- methazolamide [Substance BNPC]
- methazolamide [MeSH Descriptor]
- methazolamide [MeSH concept]
- methazolamide [SNOMED Notion]
Validated automatic mappings to BTNT
- methazolamide [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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