NCIt definition : An analogue of tetrahydrocannabinol (THC), with potential antiemetic, anxiolytic,
appetite-stimulating, analgesic, and neuroprotective activities. Delta-8-tetrahydrocannabinol
(delta-8-THC) binds to the cannabinoid G-protein coupled receptor CB1, located in
the central nervous system; CB1 receptor activation may inhibit adenyl cyclase, increase
mitogen-activated protein kinase activities, modulate several potassium channel conductances
and inhibit N- and P/Q-type Ca2 channels. This agent exhibits a lower psychotropic
potency than delta-9-tetrahydrocannabinol (delta-9-THC), the primary form of THC found
in cannabis.;