Preferred Label : Folitixorin;
NCIt synonyms : 5,10-Methylenetetrahydrofolate; Tetrahydromethylenefolate; N-(4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-glutamic
Acid; 5,10-methylene-5,6,7,8-tetrahydrofolic Acid; 5 10-Methylenetetrahydrofolate;
NCIt definition : A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate
(MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate
(FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of
thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent
of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate,
does not require metabolic activation and may increase the chemotherapeutic effects
of fluorouracil with lower toxicity.;
UNII : 0SXY5ET48B;
InChIKey : QYNUQALWYRSVHF-ABLWVSNPSA-N;
CAS number : 3432-99-3;
Drug name : CoFactor;
Chemical formula : C20H23N7O6;
ChEBI ID : CHEBI:1989;
Origin ID : C61304;
UMLS CUI : C0048858;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
