Preferred Label : TLR7 Agonist 852A;
NCIt synonyms : 852A;
NCIt related terms : 852A; CPG-52852;
NCIt definition : A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating
and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7,
thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent
signaling pathway. Activation of pDC results in secretion of interferon alpha, the
production of proimflammatory cytokines, the upregulation of co-stimulatory molecules,
and enhanced T and B-cell stimulatory responses.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain adult and childhood
blood cancers and other types of cancer. 852A may help the patient's immune system
block tumor growth. It is a type of immune system modulator.;
UNII : 6PJC3KPK6S;
CAS number : 532959-63-0;
Molecule name : 852A; PF-4878691;
Codes from synonyms : CDR0000488411;
Origin ID : C61104;
UMLS CUI : C1541384;
Semantic type(s)
- concept_is_in_subset
