NCIt definition : One of a class of antibiotics originally isolated from plant and soil bacteria with
structures containing either a glycosylated cyclic or polycyclic nonribosomal peptide.
These antibiotics inhibit the cell wall structure of susceptible organisms (principally
Gram-positive cocci) by inhibiting peptidoglycan synthesis. First-generation glycopeptide
antibiotics include vancomycin, teicoplanin, and ramoplanin; second-generation semi-synthetic
glycopeptide antibiotics include oritavancin, dalbavancin, and telavancin.;