Nedaplatin - CISMeF

Preferred Label : Nedaplatin;

NCIt synonyms : (Glycolato-O,O')diammineplatinum(II); cis-Diammine(glucolato)platinum; CDGP; NDP;

NCIt definition : A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.;

UNII : 8UQ3W6JXAN;

InChIKey : GYAVMUDJCHAASE-UHFFFAOYSA-M;

CAS number : 95734-82-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 95734-82-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : 254-S;

Chemical formula : C2H2O3.Pt.2H3N;

ChEBI ID : CHEBI:31898;

Codes from synonyms : 348;

Details

Origin ID

C61099;

UMLS CUI

C0093999;

Automatic exact mappings (from CISMeF team)
- Constitutional delay of growth and puberty [ICD-11 Sub-sub category]
- N,N-di-n-propylserotonin [MeSH Supplementary Concept]
- N,N-di-n-propylserotonin [MeSH concept]
- Norrin cystine knot growth factor ndp [OMIM gene]
- norrin cystine knot growth factor NDP [ORDO Gene]
Currated CISMeF NLP mapping
- nedaplatin [MeSH concept]
- nedaplatin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nedaplatin [MeSH Supplementary Concept]
- nedaplatin [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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