" /> Siltuximab - CISMeF





Preferred Label : Siltuximab;

NCIt synonyms : Anti-IL-6 Chimeric Monoclonal Antibody;

NCIt related terms : CNTO 328; cCLB8;

NCIt definition : A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine interleukin 6 (IL-6), with antitumor and anti-inflammatory activities. Upon intravenous administration of siltuximab, this agent targets and binds to IL-6. This inhibits the binding of IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This inhibits cancer cell growth in tumors overexpressing IL-6.;

Alternative definition : NCI-GLOSS: A chimeric (made from human and mouse proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking inflammation and tumor growth.;

UNII : T4H8FMA7IM;

CAS number : 541502-14-1;

Drug name : Sylvant;

Molecule name : CNTO-328;

NCI Metathesaurus CUI : CL776663;

Codes from synonyms : CDR0000482342; CDR0000523283; CDR0000523284; 466;

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11/07/2025


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