NCIt definition : A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine
interleukin 6 (IL-6), with antitumor and anti-inflammatory activities. Upon intravenous
administration of siltuximab, this agent targets and binds to IL-6. This inhibits
the binding of IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of
the IL-6/IL-6R-mediated signal transduction pathway. This inhibits cancer cell growth
in tumors overexpressing IL-6.;
Alternative definition : NCI-GLOSS: A chimeric (made from human and mouse proteins) monoclonal antibody being
studied in the treatment of advanced kidney cancer and other types of cancer. Monoclonal
antibodies are made in the laboratory and can locate and bind to substances in the
body, including cancer cells. Anti-IL-6 chimeric monoclonal antibody works by blocking
inflammation and tumor growth.;
UNII : T4H8FMA7IM;
CAS number : 541502-14-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 541502-14-1
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G-SRS /a ;
Drug name : Sylvant;
Molecule name : CNTO-328;
NCI Metathesaurus CUI : CL776663;
Codes from synonyms : CDR0000482342; CDR0000523283; CDR0000523284; 466;