Sodium Stibogluconate

Preferred Label : Sodium Stibogluconate;

NCIt synonyms : Antimony Sodium Gluconate;

NCIt related terms : SODIUM STIBOGLUCONATE ANHYDROUS; SSG;

NCIt definition : Pentavalent antimony (Sb) in differential complex formation with gluconic acid with leishmanicidal and potential antineoplastic activities. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phosphorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain solid tumors, lymphoma, and myeloma. Sodium stibogluconate may block enzymes needed for cancer growth. It is a type of pentavalent antimonial.;

UNII : V083S0159D;

InChIKey : OXXXHEHIUSKLPQ-JZQFZNMZSA-M;

CAS number : 12001-86-4; 16037-91-5;

Drug name : Myostibin; Lenocta; Solustin; Pentostam; Solustibosan;

Molecule name : VQD001;

Chemical formula : C12H18O17Sb2.2Na;

ChEBI ID : CHEBI:28148;

Codes from synonyms : CDR0000482341; 50554; CDR0000523297;

Details

Origin ID

C61083;

UMLS CUI

C0030895;

Currated CISMeF NLP mapping
- Sodium antimony gluconate [ICD-11 Extension code]
- Sodium stibogluconate [ICD-11 Extension code]
- Sodium stibogluconate [ICHI extension code]
- Sodium stibogluconate [SMS substance]
- Sodium stibogluconate (substance) [SNOMED CT concept]
- antimony sodium gluconate [MeSH Descriptor]
- antimony sodium gluconate [MeSH concept]
- antimony sodium gluconates [MeSH concept]
See also inter- (CISMeF)
- Product containing sodium stibogluconate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sodium stibogluconate (medicinal product) [SNOMED CT concept]
- Sodium stibogluconate [ICD-11 Extension code]
- Sodium stibogluconate (substance) [SNOMED CT concept]
- antimony sodium gluconate [MeSH Descriptor]
- sodium stibogluconate [ATC Code]
Validated automatic mappings to BTNT
- sodium stibogluconate [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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