" /> Algenpantucel-L - CISMeF





Preferred Label : Algenpantucel-L;

NCIt synonyms : Alpha (1,3) Galactosyltransferase Tumor Vaccine; Hyperacute Pancreatic Cancer Vaccine; Alpha-1,3-Galactosyltransferase-expressing Allogeneic Pancreatic Tumor Cell Vaccine; Alpha-Gal Pancreatic Cancer Vaccine;

NCIt definition : A cancer vaccine comprised of irradiated allogeneic pancreatic cancer cells transfected to express murine alpha-1,3-galactosyltransferase with potential antitumor activity. Vaccination is associated with the expression of murine alpha-1,3-galactosyl (alpha-gal) carbohydrate residues on cell membrane glycoproteins and glycolipids of the vaccine pancreatic cancer cell allograft; murine alpha-gal epitopes, not present on human cells, then induce a hyperacute rejection of the vaccine pancreatic cancer cell allograft. The hyperacute rejection involves the binding of pre-existing human anti-alpha-gal antibodies (which naturally occur against gut flora) to murine alpha-gal epitopes, resulting in the rapid activation of antibody-dependent cell-mediated cytotoxicity (ADCC) towards allograft cells. The host immune system then attacks endogenous pancreatic cancer cells, resulting in ADCC towards endogenous pancreatic cancer cells.;

UNII : I6HAD3HP89;

Drug name : HyperAcute-Pancreas Immunotherapy;

Molecule name : HAPa;

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15/05/2024


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