Preferred Label : ISS 1018 CpG Oligodeoxynucleotide;
NCIt synonyms : ISS1018 Oligodeoxynucleotide; DNA, D(P-THIO)(T-G-A-C-T-G-T-G-A-A-C-G-T-T-C-G-A-G-A-T-G-A);
NCIt related terms : 1018 ISS;
NCIt definition : A short, synthetic, unmethylated CpG motif-based oligodeoxynucleotide (CpG ODN) with
immunostimulatory activity. As an immunostimulatory sequence (ISS) that signals through
Toll-like receptor 9 (TLR9), ISS 1018 CpG ODN induces the production of immunoglobulin
by B cells and interferon (IFN) -alpha, IFN-beta, interleukin (IL) -12, and tumor
necrosis factor (TNF) -alpha by plasmacytoid dendritic cells (pDC). pDC, through cell-cell
contact, and IFN-alpha and -beta, in turn, induce natural killer (NK) cell proliferation,
NK cell production of IFN-gamma, and NK cell-mediated cytotoxicity; secreted IFNs
also stimulate bystander T cell activation and differentiation of naive CD4 T cells
into T-helper 1 cells on specific antigen challenge. In addition, ISS 1018 CpG ODN
promotes antigen presentation and co-stimulatory molecule expression.;
UNII : 25DT549L0G;
CAS number : 937402-51-2;
Molecule name : CPG 1018;
Origin ID : C61080;
UMLS CUI : C1506199;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
