Preferred Label : Paclitaxel Vitamin E-Based Emulsion;
NCIt synonyms : Paclitaxel Injectable Emulsion; PIE; Tocosol Paclitaxel;
NCIt definition : A cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation
of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits
the disassembly of microtubules, thereby resulting in the inhibition of cell division.
This agent also induces apoptosis by binding to and blocking the function of the apoptosis
inhibitor protein B-cell Leukemia 2 (Bcl-2). The vitamin-E based emulsion allows bolus
infusion without steroid premedication and may diminish hypersensitivity reactions.
The tumor tissue may be passively targeted due to preferential deposition of emulsion
particles while an emulsion formulation component inhibits the P-glycoprotein drug
efflux pump.;
Drug name : Tocosol;
Molecule name : S-8184;
Origin ID : C61079;
UMLS CUI : C1883355;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
