Preferred Label : Viagenpumatucel-L;
NCIt synonyms : Gp96-Ig Fusion Protein-Expressing Non-Small Cell Lung Cancer Cell Vaccine;
NCIt definition : A proprietary, allogeneic tumor cell vaccine expressing a recombinant secretory form
of the heat shock protein gp96 fusion (gp96-Ig) with potential antineoplastic activity.
Upon administration of viagenpumatucel-L, the irradiated live tumor cells continuously
secrete gp96-Ig along with its chaperoned tumor associated antigens (TAAs) into the
blood stream, thereby activating antigen presenting cells, natural killer cells and
priming potent cytotoxic T lymphocytes (CTLs) to respond against TAAs on the endogenous
tumor cells. Furthermore, this vaccine may induce long-lived memory T cells that could
fight recurring cancer cells. gp96-Ig is constructed by replacing the KDEL retention
sequence of gp96, normally an endoplasmatic reticulum-resident chaperone peptide,
with the Fc portion of mouse and human IgG1.;
UNII : 13H90KC831;
Molecule name : HS-110;
Origin ID : C61073;
UMLS CUI : C1831778;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
