Preferred Label : Sagopilone;
NCIt synonyms : (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione; ZK-Epothilone; ZK-EPO; ZK219477;
NCIt related terms : epothilone ZK219477;
NCIt definition : A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.
Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing
microtubules against depolymerization, which may result in the inhibition of cell
division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate
for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant
(MDR) tumors. The epothilone class of metabolites was originally isolated from the
myxobacterium Solangium cellulosum.;
Alternative definition : NCI-GLOSS: A form of the substance epothilone that is made in the laboratory. It is
being studied in the treatment of some types of cancer. Epothilone ZK2219477 stops
the growth of tumor cells by blocking cell division. It is a type of antimitotic agent.;
UNII : KY72JU32FO;
InChIKey : BFZKMNSQCNVFGM-UCEYFQQTSA-N;
CAS number : 305841-29-6;
Molecule name : SH-Y03757A; DE-03757; ZK-219477;
Chemical formula : C30H41NO6S;
Codes from synonyms : CDR0000537170;
Origin ID : C61072;
UMLS CUI : C2355512;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
- has_target
