Preferred Label : Aerosolized Liposomal Rubitecan;
NCIt synonyms : Aerosolized liposomal 9-nitro-20(S)-camptothecin; Aerosolized Liposomal 9-Nitrocamptothecin;
NCIt definition : An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of
camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin)
and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase
I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase
I-mediated single-strand DNA breaks and producing potentially lethal double-strand
DNA breaks when encountered by the DNA replication machinery. This agent is formulated
with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer
mass median aerodynamic diameter.;
Origin ID : C61071;
UMLS CUI : C2828334;
Semantic type(s)
- concept_is_in_subset
