Preferred Label : Recombinant Bispecific Single-Chain Antibody rM28;
NCIt definition : A recombinant, bispecific, single-chain antibody directed against both the T-cell
surface-associated costimulatory molecule CD28 and a melanoma-associated proteoglycan
(MAPG) with potential antitumor activity. By targeting both CD28 and MAPG, recombinant
bispecific single-chain antibody rM28 enhances cytotoxic T-cell recognition of melanoma
cells, which may result in immune effector cell-mediated tumor cell death and a decrease
in distant metastases. This agent appears to have a long serum half-life secondary
to the formation of dimers. When activated, CD28 facilitates interactions between
T-cells and other immune effector cells resulting in cytotoxic T-lymphocyte responses;
MAPG is a surface antigen expressed on the majority of melanomas, including primary
cutaneous, ocular, and metastatic melanomas.;
Molecule name : rM28;
Origin ID : C60882;
UMLS CUI : C1831730;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
