" /> HMGCR wt Allele - CISMeF





Preferred Label : HMGCR wt Allele;

NCIt synonyms : 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase wt Allele; Hydroxymethylglutaryl-CoA Reductase Gene; LDLCQ3; 3-Hydroxy-3-Methylglutaryl CoA Reductase (NADPH) Gene;

NCIt definition : Human HMGCR wild-type allele is located within 5q13.3-q14 and is approximately 25 kb in length. This allele, which encodes 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein, plays a role in the regulation of cholesterol biosynthesis.;

NCIt note : Statins, a class of hypolipidemic agents, are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein. These drugs are used to lower cholesterol levels in individuals who exhibit hypercholesterolemia and, therefore, are at risk for cardiovascular disease. Heritable polymorphisms in the HMGCR gene are associated with the reduced efficacy of statin therapy in lowering cholesterol levels.;

GenBank Accession Number : NM_000859;

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20/05/2024


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