Preferred Label : Polyamine Analogue PG11047;
NCIt synonyms : N(1),-N(12)-bis(ethyl)-cis-6,7-dehydrospermine tetrahydrochloride; N(1),N(12)-bisethylspermine; N(1),-N(12)-bis(ethyl)-cis-6,7-dehydrospermine; BESpm;
NCIt related terms : CGC-11047; SL-11047;
NCIt definition : A second generation polyamine analogue, synthesized through the restriction of molecular
conformations of parent polyamine compounds, with potential antineoplastic activity.
Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites,
thereby interfering with cell cycle processes dependent upon polyamine binding and
function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of
polyamines, and interference with gene and ligand-receptor activities involved with
cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles
compared to first-generation polyamine compounds. In tumor cells, there is an increase
dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting
in abnormal or sustained tumor growth.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of lymphoma. It belongs
to the family of drugs called polyamine analogs.;
UNII : HU43305R7O;
CAS number : 206991-64-2;
Molecule name : PG11047; SL11047; CGC-11047;
Codes from synonyms : CDR0000471778;
Origin ID : C60816;
UMLS CUI : C4520809;
See also inter- (CISMeF)
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
