NCIt definition : An isolate of the oncolytic, human wild-type serotype 3 Dearing (T3D) strain of the
double-stranded RNA virus reovirus (Respiratory Enteric Orphan virus), with potential
oncolytic activity. Upon administration, pelareorep is able to replicate specifically
in cancer cells bearing an activated Ras pathway. This induces apoptosis in Ras-activated
tumor cells and subsequently frees progeny viral particles to infect, replicate in
and induce cell death of surrounding cancer cells. In addition, viral replication
causes the activation of innate and adaptive immune responses, causing a natural killer
(NK)-cell-mediated and a cytotoxic T-cell (CTL)-mediated killing of tumor cells, respectively.
Ras-activated tumor cells are deficient in their ability to trigger the antiviral
response mediated by the host cellular protein, double-stranded RNA-dependent protein
kinase (PKR).;
Automatic exact mappings (from CISMeF team)