Preferred Label : Smoothened Antagonist IPI-609;
NCIt related terms : IPI-269609;
NCIt definition : A semi-synthetic cyclopamine analogue and an inhibitor of SMO and the Hedgehog (Hh)
pathway, with potential antineoplastic activity. Upon administration, smoothened antagonist
IPI-609 targets, binds to and inhibits the cell membrane-spanning G-protein coupled
receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease
in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand
to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling
and uncontrolled cellular proliferation may be associated with SMO mutations.;
UNII : 0E0K1H745W;
CAS number : 878204-96-7;
Molecule name : IPI-269609; IPI-609; IPI 609; IPI 269609;
Origin ID : C60772;
UMLS CUI : C1881124;
Semantic type(s)
- concept_is_in_subset
- has_target
