Preferred Label : Recombinant Interleukin;
NCIt synonyms : Interleukins; Therapeutic Interleukin;
NCIt definition : Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins.
Produced by T cells, macrophages, and other cells, interleukins bind to a specific
surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic
effects including stimulation of growth, differentiation, and proliferation of lymphocytes
and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell
activity; activation of the acute phase response; and stimulation of hematopoiesis.
Some interleukins may enhance the host's immune response to malignant cells by stimulating
lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL),
which are capable of lysing some tumor cells. (NCI04);
Origin ID : C593;
UMLS CUI : C1527200;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_physiologic_effect
