Preferred Label : Stage IV Major Salivary Gland Cancer AJCC v7;
NCIt synonyms : Stage IV Major Salivary Gland Carcinoma AJCC v7; Stage IV Carcinoma of the Major Salivary Gland; Stage IV Carcinoma of Major Salivary Gland; Stage IV Major Salivary Gland Carcinoma;
NCIt related terms : Stage IV Major Salivary Gland Cancer; stage IV salivary gland cancer;
NCIt definition : Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3,
N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); (Any T, N3, M0); IVC (Any T, Any N,
M1). T4a: Moderately advanced disease. Tumor invades skin, mandible, ear canal, and/or
facial nerve. T1: Tumor measuring 2 cm or less in greatest dimension without extraparenchymal
extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion
of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension
for classification purposes. T2: Tumor measuring more than 2 cm, but not more than
4 cm in greatest dimension without extraparenchymal extension. T3: Tumor measuring
more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension.
T4b: Very advanced disease. Tumor invades skull base and/or pterygoid plates and/or
encases carotid artery. N0: No regional lymph node metastasis. N1: Metastasis in a
single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis
in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest
dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest
dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest
dimension. N3: Metastasis in a lymph node, more than 6 cm in greatest dimension. M0:
No distant metastasis. M1: Distant metastasis. (AJCC 7th ed.);
Alternative definition : NCI-GLOSS: Stage IV salivary gland cancer is divided into stages IVA, IVB, and IVC.
In stage IVA, (1) cancer has spread to one or more lymph nodes on either or both sides
of the body and the lymph nodes are not larger than 6 centimeters; the tumor may be
any size and may have spread to soft tissue around the affected gland; or (2) cancer
has spread to the skin, jawbone, ear canal, and/or facial nerve, and may have spread
to one or more lymph nodes on either or both sides of the body; the lymph nodes are
not larger than 6 centimeters. In stage IVB, (1) cancer has spread to a lymph node
larger than 6 centimeters; the tumor may be any size and may have spread to soft tissue
around the affected gland; or (2) cancer has spread to the base of the skull and/or
the carotid artery, and may have spread to one or more lymph nodes of any size on
either or both sides of the body. In stage IVC, cancer has spread to distant parts
of the body.;
Neoplastic status : Malignant;
Codes from synonyms : CDR0000446190;
Origin ID : C5898;
UMLS CUI : C4520742;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
