Preferred Label : Recombinant Interferon;
NCIt synonyms : Human Leukocyte Interferon; Human Lymphoblastoid Interferon; IFN; Therapeutic Interferon;
NCIt related terms : Interferons;
NCIt definition : One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative,
and immunomodulating activities. Interferons bind to specific cell-surface receptors,
leading to the transcription and translation of genes with interferon-specific response
elements (ISREs). The resultant proteins mediate many complex effects, ultimately
leading to inhibition of viral protein synthesis and cellular growth, alteration of
cellular differentiation, interference with oncogene expression, activation of natural
killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte
and macrophage cytotoxicity. The production of endogenous interferons is induced in
response to foreign agents such as bacteria, viruses and parasites and to tumor cells.;
CAS number : 9008-1-11;
Codes from synonyms : NSC0339140; 00337;
Origin ID : C584;
UMLS CUI : C1522537;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
