NCIt synonyms : Mesenchymal Hamartoma of Liver; Mesenchymal Hamartoma of the Liver; Liver MH; Hepatic Mesenchymal Hamartoma; HMH;
NCIt definition : A multicystic mesenchymal tumor that arises from the liver during fetal development.
It is the third most common pediatric liver tumor following hepatoblastoma and infantile
hemangioma. Cytogenetic and molecular studies have revealed the presence of chromosomal
rearrangements involving chromosome 19q13.4 or androgenetic-biparental mosaicism.
These findings support the evidence that it is a neoplastic process and not only a
developmental process. Clinically, it usually presents as an abdominal mass associated
with abdominal distention. Morphologically, it consists of hypocellular fibromyxoid
stroma and bland spindle cell proliferation. It generally has a benign clinical course.
Following resection, the prognosis is good.;