NCIt definition : A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin,
produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding
proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are
enzymes that are involved in the last stages of assembling the bacterial cell wall
and in reshaping the cell wall during growth and division. This inactivation results
in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem
has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related
to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive
and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05);
Alternative definition : NCI-GLOSS: An antibiotic drug used to treat severe or very resistant infection. It
belongs to the family of drugs called carbapenems.;