Lung Large Cell Neuroendocrine Carcinoma

Preferred Label : Lung Large Cell Neuroendocrine Carcinoma;

NCIt synonyms : Pulmonary Large Cell Neuroendocrine Carcinoma; Large Cell Neuroendocrine Carcinoma of the Lung; Large Cell Neuroendocrine Carcinoma of Lung; Large Cell Lung Carcinoma with Neuroendocrine Differentiation; Large Cell Neuroendocrine Lung Carcinoma; LCNEC of the Lung; Large Cell Lung Neuroendocrine Carcinoma;

NCIt definition : A carcinoma with neuroendocrine differentiation that arises from the lung. It is characterized by the presence of malignant large cells, more than 10 mitoses per 2 mm2, and necrosis. It usually has an aggressive clinical course.;

Neoplastic status : Malignant;

Details

Origin ID

C5672;

UMLS CUI

C1334363;

Automatic exact mappings (from CISMeF team)
- pulmonary large cell neuroendocrine carcinoma [DO Concept]
Currated CISMeF NLP mapping
- large cell neuroendocrine lung carcinoma [Disease (Nov.)]
DO Cross reference
- pulmonary large cell neuroendocrine carcinoma [DO Concept]
Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Neuroendocrine Small Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Endothelial Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease excludes normal cell origin
- Endothelial Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Cough [NCIt concept]
- Dyspnea [NCIt concept]
- Fever [NCIt concept]
- Hemoptysis [NCIt concept]
- Neuron-Specific Enolase Positive Neoplastic Cells Present [NCIt concept]
- Rosette Formation [NCIt concept]
- Sheet-Like Growth Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
Has associated anatomic sites
- Lung [NCIt concept]
- Respiratory System [NCIt concept]
- Thoracic Cavity [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- large cell neuroendocrine lung carcinoma [Disease (Nov.)]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Glandular Differentiation [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Premalignant Lesion [NCIt concept]
- Squamous Differentiation [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Epithelial Large Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Neuroendocrine Large Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Expression of Neuroendocrine Markers Present [NCIt concept]
- High Grade Lesion [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- More than 10 Mitoses per 10HPF [NCIt concept]
- Necrotic Change [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Nuclear Molding [NCIt concept]
- Peripheral Nuclear Palisading [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Lung [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- C-KIT Tyrosine Kinase Protein Overexpression [NCIt concept]
- CDKN2A Gene Deletion [NCIt concept]
- FGFR1 Gene Amplification [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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