IgE - CISMeF

Preferred Label : IgE;

NCIt synonyms : Immunoglobulin E;

NCIt definition : An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general.;

Details

Origin ID

C567;

UMLS CUI

C0020846;

Currated CISMeF NLP mapping
- IgE [LOINC component]
- IgE [MedDRA LLT]
- Immunoglobulin E [FMA entity]
- Immunoglobulin E [MedDRA LLT]
- Immunoglobulin E (substance) [SNOMED CT concept]
- immunoglobulin E [COVID-19 Thesaurus concept]
- immunoglobulin E [MeSH concept]
- immunoglobulin e [MeSH Descriptor]
- immunoglobulins, e [Substance BNPC]
False automatic mappings
- Epilepsy, idiopathic generalized [OMIM Phenotype]
- Imerslund-Grasbeck syndrome [ICD-11 More detail]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IgE [LOINC part]
- IgE [LOINC component]
- IgE Ab [LOINC component]
- Immunoglobulin E [FMA entity]
- Immunoglobulin E (substance) [SNOMED CT concept]
- immunoglobulin E [MeSH concept]
- immunoglobulin e [MeSH Descriptor]
- immunoglobulin ige, nos [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
gene_product_has_biochemical_function
- Antibody [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Binding [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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