" /> Idoxuridine - CISMeF





Preferred Label : Idoxuridine;

NCIt synonyms : IUdR; 5-iodo-2'-deoxyuridine; 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil; 2'-Deoxy-5-iodouridine; Iododeoxyuridine; IDU; IDUR; Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-; 1beta-D-2'-Deoxyribofuranosyl-5-iodouracil; Uridine, 2'-deoxy-5-iodo-; 5-IUdR; IdURD; 1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil; 5-Iododeoxyuridine;

NCIt related terms : Herplex; Iduridin; Idoxene; Kerecid; Idulea; SKF 14287; Dendrid; Stoxil; Idexur;

NCIt definition : An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.;

Alternative definition : NCI-GLOSS: A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.;

UNII : LGP81V5245;

InChIKey : XQFRJNBWHJMXHO-RRKCRQDMSA-N;

CAS number : 54-42-2;

Drug name : Idulea; Stoxil; Herplex; Virudox; Idoxene; Idexur; Kerecid; Iduridin; Dendrid;

Molecule name : SKF 14287;

Chemical formula : C9H11IN2O5;

NSC code : 39661;

ChEBI ID : CHEBI:147675;

Codes from synonyms : CDR0000045219; NSC0039661;

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28/05/2025


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