NCIt definition : A lipoxygenase metabolite of arachidonic acid and an intermediate in the pathway of
leukotriene synthesis. 5-hydroxyeicosatetraenoic acid (5-HETE) is also a modulator
of tubuloglomerular feedback, one of the mechanism the kidney uses to regulate glomerular
filtration rate. Along with leukotriene B4, 5-HETE is often used as biomarker in evaluating
eicosanoid metabolism and disease state.;