" /> INTS6 wt Allele - CISMeF





Preferred Label : INTS6 wt Allele;

NCIt synonyms : DDX26; INT6; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B Gene; DKFZP434B105; HDB; DBI-1; NOTCHL2; Integrator Complex Subunit 6 wt Allele; DICE1; Deleted in Cancer 1; DDX26 wt Allele;

NCIt definition : Human INTS6 wild-type allele is located within 13q14.12-q14.2 and is approximately 92 kb in length. This allele, which encodes integrator complex subunit 6 protein, may play a role in the regulation of both small nuclear RNA transcription and RNA polymerase II activity.;

NCIt note : The INTS6 gene encodes a highly conserved protein, which contains both a vWF type A domain and a DEAD box. A major 4.4-, and a minor 6.9-kb, transcript is expressed in a wide variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. This gene is a candidate tumor suppressor because it is located in a critical loss of heterozygosity region. Prostate cancers may exhibit aberrant reduced expression of this gene due to hypermethylation of its promoter. (Entrez Gene and SwissProt);

GenBank Accession Number : AF097645;

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12/05/2024


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