NCIt definition : Human PVT1 wild-type allele is located in the vicinity of 8q24.21 and is approximately
307 kb in length. This allele, which encodes Pvt1 oncogene long non-coding RNA, may
play a role in the regulation of the expression of the MYC gene. Overexpression of
the PVT1 gene is associated with the development of Burkitt lymphoma, breast and ovarian
cancers, acute myeloid leukemia and Hodgkin lymphoma; variations in this gene are
associated with end-stage renal disease attributed to type 1 diabetes.;
NCIt note : The PVT1 gene region in mice is involved in some plasmacytomas. The gene product for
the human PVT1 is a non-coding RNA. (Entrez Protein references discontinued).;