" /> CEACAM5 wt Allele - CISMeF





Preferred Label : CEACAM5 wt Allele;

NCIt synonyms : CD66e; CEA; CEACAM5; Carcinoembryonic Antigen Related Cell Adhesion Molecule 5 wt Allele; Carcinoembryonic Antigen Gene; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Gene;

NCIt definition : Human CEACAM5 wild-type allele is located within 19q13.1-q13.2 and is approximately 21 kb in length. This allele, which encodes carcinoembryonic antigen-related cell adhesion molecule 5 protein, is involved in the facilitation of hepatic metastasis. The wild-type function is currently unknown, however allelic variants have been implicated in several cancers.;

NCIt note : This gene belongs to the CEA family of genes. It encodes carcinoembryonic antigen-related cell adhesion molecule 5, a complex immunoreactive glycoprotein with a molecular weight of 180,000 comprising 60% carbohydrate. This gene comprises 9 exons encoding amino acids and 1 encoding a 3-prime untranslated fragment. Originally thought to be a specific antigen of the fetal digestive tract and adenocarcinoma of the colon, the gene product is known to occur normally in feces and pancreaticobiliary secretions and to appear in the plasma in a diverse group of neoplastic and non-neoplastic conditions. It is implicated as a facilitator of hepatic metastasis.;

GenBank Accession Number : NM_004363;

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27/04/2024


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