Preferred Label : BCPR wt Allele;
Obsolete resource : true;
NCIt synonyms : BCPR; Breast Cancer-Related Regulator of TP53 wt Allele;
NCIt definition : Human BCPR wild-type allele is located in the vicinity of 5p13.3 and the length of
the gene is currently unknown. This allele, which encodes breast cancer-related regulator
of TP53 protein, plays a role in tumor suppression.;
NCIt note : Defined by D17S926, D17S695, and D17S849, which map close together in a region of
high loss of heterozygosity (60%), BCPR gene appears to be associated with over expression
of p53 mRNA, suggesting a gene located some twenty megabases telomeric to TP53 that
regulates its expression. Lesions of this regulatory gene seem to be involved in most
breast cancers.; Interim Gene Symbol and Name; See 'BCPR Gene(C20776)';
Concept status : Retired_Concept;
Origin ID : C54375;
UMLS CUI : C1704961;
OMIM relation
- Semantic type(s)
