Laryngeal Spindle Cell Squamous Carcinoma

Preferred Label : Laryngeal Spindle Cell Squamous Carcinoma;

NCIt synonyms : Laryngeal Sarcomatoid Carcinoma; Laryngeal Carcinosarcoma; Laryngeal Squamous Cell Carcinoma Spindle Cell Variant; Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant; Laryngeal Spindle Cell Carcinoma;

NCIt definition : A squamous cell carcinoma that arises from the larynx. It is characterized by the presence of a malignant spindle cell cellular component. In some cases, there is a biphasic morphology due to the presence of a well-differentiated squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma.;

Neoplastic status : Malignant;

Details

Origin ID

C54336;

UMLS CUI

C1708656;

Automatic exact mappings (from CISMeF team)
- Squamous cell carcinoma of the larynx [ORDO Disease]
Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Airway Obstruction [NCIt concept]
- Dysphagia [NCIt concept]
- Hoarseness [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Larynx [NCIt concept]
- Neck [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Epithelial Spindle Cell [NCIt concept]
- Malignant Spindle Squamous Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Poorly Differentiated Lesion [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Squamous Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Laryngeal Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Larynx [NCIt concept]
- Neck [NCIt concept]
- Throat [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 11q13 [NCIt concept]
- Gain of Chromosome 14 [NCIt concept]
- Gain of Chromosome 17q [NCIt concept]
- Gain of Chromosome 1q [NCIt concept]
- Gain of Chromosome 3q [NCIt concept]
- Gain of Chromosome 5p [NCIt concept]
- Gain of Chromosome 7p [NCIt concept]
- Gain of Chromosome 7q [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Gain of Chromosome 9q [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
disease_may_have_molecular_abnormality
- EGFR Protein Overexpression [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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