Laryngeal Basaloid Squamous Cell Carcinoma

Preferred Label : Laryngeal Basaloid Squamous Cell Carcinoma;

NCIt synonyms : Laryngeal Basaloid Carcinoma;

NCIt definition : An aggressive variant of squamous cell carcinoma that arises from the pyriform sinus or supraglottic area. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. An in situ or invasive keratinizing squamous cell carcinoma component is always present. Signs and symptoms include hoarseness, dysphagia, pain, and neck mass.;

Neoplastic status : Malignant;

Details

Origin ID

C54334;

UMLS CUI

C1708650;

Currated CISMeF NLP mapping
- Basaloid carcinoma of larynx [ICD-11 More detail]
Disease excludes abnormal cell
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Airway Obstruction [NCIt concept]
- Cough [NCIt concept]
- Dysphagia [NCIt concept]
- Hemoptysis [NCIt concept]
- Hoarseness [NCIt concept]
- Pain [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Larynx [NCIt concept]
- Neck [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Hyperchromatic Epithelial Cell [NCIt concept]
- Malignant Hyperchromatic Squamous Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Monomorphic Cellular Infiltrate [NCIt concept]
- Peripheral Nuclear Palisading [NCIt concept]
- Rapidly Enlarging Mass [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Squamous Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Laryngeal Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Larynx [NCIt concept]
- Neck [NCIt concept]
- Throat [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 11q13 [NCIt concept]
- Gain of Chromosome 14 [NCIt concept]
- Gain of Chromosome 17q [NCIt concept]
- Gain of Chromosome 1q [NCIt concept]
- Gain of Chromosome 3q [NCIt concept]
- Gain of Chromosome 5p [NCIt concept]
- Gain of Chromosome 7p [NCIt concept]
- Gain of Chromosome 7q [NCIt concept]
- Gain of Chromosome 8q [NCIt concept]
- Gain of Chromosome 9q [NCIt concept]
- Loss of Chromosome 18q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
disease_may_have_molecular_abnormality
- EGFR Protein Overexpression [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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