NCIt synonyms : Melanoma Antigen Family A, 12 wt Allele; MAGE12;
NCIt definition : Human MAGEA12 wild-type allele is located in the vicinity of Xq28 and is approximately
26 kb in length. This allele, which encodes melanoma-associated antigen 12 protein,
is involved in the mediation of tumor cell recognition by cytotoxic T-cells and may
play a role in spermatogenesis.;
NCIt note : The MAGEA12 gene is a member of the MAGEA gene family. Genes in this family are expressed
in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
lung carcinoma and breast carcinoma, but not in normal tissues except for testes and
placenta or in kidney tumors, leukemias and lymphomas. (Entrez Gene and SwissProt);