Preferred Label : Paraneoplastic Subacute Sensory Neuronopathy;
NCIt synonyms : Paraneoplastic Subacute Sensory Neuropathy;
NCIt definition : A sensory neuropathy caused by the effects of a distant neoplasm (usually a small
cell carcinoma). It is usually caused by the production of anti-neuronal autoantibodies:
anti-Hu (ANNA-1) or anti-CV2 (CRMP-5), which result in cytotoxic T-cell mediated destruction
of dorsal root ganglia. It is the most common clinical presentation of paraneoplastic
encephalomyelitis. Clinical signs include asymmetric paresthesia of the face, trunk
and proximal extremities followed by lancinating pain, vibrioceptive and proprioceptive
impairment, and muted reflexes. Clinical course usually follows a progressive neurologic
deterioration which stabilizes at a level of severe, permanent disability.;
Origin ID : C5420;
UMLS CUI : C1335344;
Automatic exact mappings (from CISMeF team)
- Has associated anatomic sites
- Semantic type(s)
