Basal-Like Breast Carcinoma

Preferred Label : Basal-Like Breast Carcinoma;

NCIt synonyms : Basal-Like Subtype of Breast Carcinoma; Basal-Like Subtype of Invasive Breast Carcinoma; Basal-Like Breast Cancer;

NCIt definition : A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis.;

Neoplastic status : Malignant;

Details

Origin ID

C53558;

UMLS CUI

C3642347;

Automatic exact mappings (from CISMeF team)
- Basal-like carcinoma of breast [ICD-11 Extension code]
Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Aggressive Clinical Course [NCIt concept]
- Estrogen Receptor Negative [NCIt concept]
- HER2/Neu Negative [NCIt concept]
- Progesterone Receptor Negative [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Breast [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- EGFR Protein Overexpression [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Mammary Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Breast [NCIt concept]
disease_mapped_to_gene
- EGFR Gene [NCIt concept]
- KRT17 Gene [NCIt concept]
- KRT5 Gene [NCIt concept]

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