Preferred Label : Diindolylmethane;
NCIt synonyms : Di-Indoly Methane; 3,3'-Methylenebis-1H-indole; 3,3'-Diindolymethane;
NCIt related terms : 3,3'-DIINDOLYLMETHANE; DIM;
NCIt definition : A phytonutrient and plant indole found in cruciferous vegetables including broccoli,
Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and
antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM)
promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy
estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites,
resulting in increased antioxidant activity. Although this agent induces apoptosis
in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic
activity in vivo is unknown.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of prostate cancer and in the
prevention of cervical cancer. Diindolylmethane is found in cruciferous vegetables
like broccoli, brussels sprouts, cauliflower, cabbage, and kale. It is a type of plant
indole.;
UNII : SSZ9HQT61Z;
CAS number : 1968-05-4;
Drug name : DIMPRO; DIM-Plus;
Molecule name : CCRIS 5806;
ChEBI ID : CHEBI:50182;
Codes from synonyms : CDR0000489306; CDR0000523294; 05123;
Origin ID : C53434;
UMLS CUI : C0163151;
Semantic type(s)
- concept_is_in_subset
