Preferred Label : ADH-1;
NCIt definition : A small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic
and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks
N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor
cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin,
a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins
involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated
in some aggressive tumors and the endothelial cells and pericytes of some tumor blood
vessels.;
UNII : B058ME29VU;
CAS number : 229971-81-7;
Drug name : Exherin;
Origin ID : C53399;
UMLS CUI : C1706643;
Semantic type(s)
- concept_is_in_subset
- has_target
