Dacomitinib - CISMeF

Preferred Label : Dacomitinib;

NCIt synonyms : EGFR Inhibitor PF-00299804; (2E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-yl)-4-Piperidin-1-ylbut-2-Enamide;

NCIt related terms : PF-00299804;

NCIt definition : A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein tyrosine kinase inhibitors.;

UNII : 5092U85G58;

InChIKey : BSPLGGCPNTZPIH-IPZCTEOASA-N;

CAS number : 1042385-75-0;

Drug name : Vizimpro;

Molecule name : PF-00299804; PF-00299804-03; PF-299804; PF 00299804;

Chemical formula : C24H25ClFN5O2.H2O;

Codes from synonyms : CDR0000468787; 133;

Details

Origin ID

C53398;

UMLS CUI

C2987430;

Automatic exact mappings (from CISMeF team)
- Dacomitinib [ICD-11 Extension code]
- dacomitinib [ATC Code]
Currated CISMeF NLP mapping
- Dacomitinib (substance) [SNOMED CT concept]
- dacomitinib [MeSH concept]
- dacomitinib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- PF 00299804 [MeSH concept]
- Product containing dacomitinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dacomitinib (substance) [SNOMED CT concept]
- Product containing dacomitinib (medicinal product) [SNOMED CT concept]
- dacomitinib [MeSH concept]
- dacomitinib [MeSH Supplementary Concept]
- dacomitinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Dacomitinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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