" /> Dacomitinib - CISMeF





Preferred Label : Dacomitinib;

NCIt synonyms : EGFR Inhibitor PF-00299804; (2E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-yl)-4-Piperidin-1-ylbut-2-Enamide;

NCIt related terms : PF-00299804;

NCIt definition : A highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein tyrosine kinase inhibitors.;

UNII : 5092U85G58;

InChIKey : BSPLGGCPNTZPIH-IPZCTEOASA-N;

CAS number : 1042385-75-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1042385-75-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Vizimpro;

Molecule name : PF-00299804; PF-00299804-03; PF-299804;

Chemical formula : C24H25ClFN5O2.H2O;

Codes from synonyms : CDR0000468787; 133;

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15/05/2024


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